Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189088 | 0.87 | PTGDR2 (0.36) | PRCPLOXL2 | |
| SCHEMBL6189080 | 0.80 | KMO (0.36) | LOXL2 | |
| SCHEMBL8133903 | 0.78 | HDAC1 (0.31) | — | |
| SCHEMBL8309987 | 0.78 | LMNA (0.42) | — | |
| SCHEMBL6502262 | 0.76 | ACP3 (0.35) | — | |
| SCHEMBL4832918 | 0.75 | RIOK2 (0.44) | — | |
| SCHEMBL7861158 | 0.74 | HDAC4 (0.42) | — | |
| SCHEMBL6249531 | 0.74 | CES2 (0.33) | — | |
| SCHEMBL7502772 | 0.74 | PNMT (0.42) | — | |
| SCHEMBL6510115 | 0.73 | MAPK14 (0.34) | KCNH2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032141-A1 | INHIBITORS OF JANUS KINASES | Merck & Co., Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007145957-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |