SCHEMBL8309987

SCHEMBL8309987

O=CC(c1ccncc1)c1ccc(Br)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.42
KMT2A Q03164 2/20 0.41
CYP19A1 P11511 2/20 0.38
RAB9A P51151 4/20 0.37
NPC1 O15118 3/20 0.37
ALDH1A1 P00352 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KDM4E B2RXH2 3/20 0.34
CYP2C19 P33261 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP3A4 P08684 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2145850 0.80 ALDH1A1 (0.39) KMT2ARAB9ANPC1ALDH1A1MAPT
SCHEMBL5184111 0.80 CYP19A1 (0.61) KMT2ACYP19A1ALDH1A1HSD17B10CYP11B1
SCHEMBL6504970 0.80 CYP19A1 (0.39) LMNAKMT2ACYP19A1RAB9ANPC1
SCHEMBL2789136 0.80 LTA4H (0.42) KMT2ACYP19A1RAB9ACYP11B1
SCHEMBL1515763 0.79 SLC6A3 (0.58) LMNAKMT2AALDH1A1MAPTHSD17B10
SCHEMBL1515746 0.79 HTR2A (0.50) LMNAKMT2AALDH1A1SLC6A2SLC6A4
SCHEMBL4312752 0.78 BRAF (0.34)
SCHEMBL26999421 0.78 ALOX15 (0.54) LMNAKMT2AALDH1A1MAPTHPGD
SCHEMBL26999435 0.78 ALDH1A1 (0.54) LMNAKMT2AALDH1A1HPGDCYP2C19
SCHEMBL5921850 0.77 KIF11 (0.48) CYP19A1CYP2C19CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2922842-A2 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A AbbVie Inc. (US) 2015-09-30 EP disclosed
WO-2014079995-A2 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A ABBVIE INC. (US) 2014-05-30 WO disclosed
EP-0948257-A4 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO INC (US) 1999-12-29 EP disclosed
EP-0948257-A1 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE Merck & Co., Inc. (US) 1999-10-13 EP disclosed
US-5955480-A GLUCAGON RECEPTOR ANTAGONISTS, CYTOKINE INHIBITORS MERCK & CO., INC. (US) 1999-09-21 US disclosed
WO-1998021957-A1 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1998-05-28 WO disclosed