Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7422241

COc1ccc(CCN(CCc2ccc(OC)cc2)C(=O)C(N)C(N)=O)cc1.O=C(O)C(F)(F)F

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 3/20 0.44
ALOX5 P09917 3/20 0.44
LDHA P00338 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALOX15 P16050 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
LPAR1 Q92633 1/20 0.42
LPAR5 Q9H1C0 1/20 0.42
MEN1 O00255 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4313499 0.79 KDM4E (0.47) ALOX5LDHAKDM4EALOX15TDP1
Trifluoroacetic Acid SCHEMBL7419549 0.79 CES1 (0.44) AOC3ALOX5KDM4EMEN1CYP2D6
Trifluoroacetic Acid SCHEMBL4277212 0.76 ALOX5 (0.46) AOC3ALOX5KDM4EALOX15TDP1
Trifluoroacetic Acid SCHEMBL4313504 0.74 ALOX15 (0.47) ALOX5LDHAKDM4EALOX15TDP1
Trifluoroacetic Acid SCHEMBL7104230 0.74 SMN1; SMN2 (0.56) KMT2A
Trifluoroacetic Acid SCHEMBL4277214 0.74 ALOX5 (0.47) AOC3ALOX5
Trifluoroacetic Acid SCHEMBL4315300 0.73 KDM4E (0.42) ALOX5LDHAKDM4EALOX15TDP1
SCHEMBL27882351 0.72 ALOX5 (0.63) AOC3ALOX5TDP1LPAR1LPAR5
Trifluoroacetic Acid SCHEMBL5655817 0.72 HTT (0.51) LDHACYP3A4CYP2C19
Trifluoroacetic Acid SCHEMBL6317983 0.72 LDHA (0.54) LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140818-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE Aventis Pharmaceuticals Inc. (US) 2001-10-10 EP disclosed
WO-2000040552-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMACEUTICALS INC. (US) 2000-07-13 WO disclosed