Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CRY1 | Q16526 | 6/20 | 0.39 |
| ▸ | CRY2 | Q49AN0 | 6/20 | 0.39 |
| ▸ | PER2 | O15055 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MYLK | Q15746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734333 | 0.87 | DNM1 (0.49) | DNM1KDM4ESMN1; SMN2CRY1CRY2 | |
| SCHEMBL734385 | 0.69 | DNM1 (0.55) | DNM1KDM4ESMN1; SMN2CRY1CRY2 | |
| SCHEMBL734760 | 0.67 | DHFR (0.40) | LMNAMAPTL3MBTL1 | |
| SCHEMBL18862339 | 0.59 | KDM4E (0.97) | DNM1KDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL735924 | 0.58 | ALDH1A1 (0.44) | DNM1KDM4ESMN1; SMN2CRY1CRY2 | |
| SCHEMBL15383951 | 0.57 | PER2 (1.00) | DNM1SMN1; SMN2CRY1CRY2PER2 | |
| SCHEMBL4878312 | 0.56 | MYLK (0.73) | DNM1SMN1; SMN2CRY1CRY2PER2 | |
| SCHEMBL20462136 | 0.56 | PER2 (0.63) | DNM1KDM4ECRY1CRY2PER2 | |
| SCHEMBL8113510 | 0.56 | MYLK (1.00) | DNM1MYLK | |
| SCHEMBL21467809 | 0.55 | DNM1 (0.71) | DNM1SMN1; SMN2CRY1CRY2PER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | claimed |