Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331843 | 0.98 | NAPRT (0.39) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL4322764 | 0.79 | TSHR (0.38) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL4332440 | 0.75 | TSHR (0.35) | ALDH1A1KMT2AMAPTTSHRNR1I2 | |
| SCHEMBL11840108 | 0.73 | JAK2 (0.47) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL4752960 | 0.72 | NAPRT (0.53) | ALDH1A1KMT2AMEN1MAPTNAPRT | |
| SCHEMBL11724195 | 0.68 | ALDH1A1 (0.44) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL4334419 | 0.67 | SMURF1 (0.43) | ALDH1A1KMT2AMEN1MAPTPARP1 | |
| SCHEMBL4323167 | 0.67 | SMURF1 (0.41) | PARP1PARP2MAPK1 | |
| SCHEMBL17035412 | 0.67 | SMURF1 (0.41) | PARP1PARP2PARP3 | |
| SCHEMBL4324232 | 0.67 | SMURF1 (0.43) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4268626-A | Dry image forming material | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-05-19 | — | — | US | claimed |
| US-20230301970-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS PHARMACEUTICALS UK LIMITED (GB) | 2023-09-28 | — | — | US | disclosed |
| US-20230301970-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS PHARMACEUTICALS UK LIMITED (GB) | 2023-09-28 | — | — | US | disclosed |
| US-20230301970-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS PHARMACEUTICALS UK LIMITED (GB) | 2023-09-28 | — | — | US | disclosed |
| US-11672782-B2 | Carboxamide derivatives | NOVARTIS AG (CH) | 2023-06-13 | — | — | US | disclosed |
| US-11672782-B2 | Carboxamide derivatives | NOVARTIS AG (CH) | 2023-06-13 | — | — | US | disclosed |
| US-11672782-B2 | Carboxamide derivatives | NOVARTIS AG (CH) | 2023-06-13 | — | — | US | disclosed |
| EP-3143018-B1 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2021-03-10 | — | — | EP | disclosed |
| US-20210052554-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS PHARMACEUTICALS UK LIMITED (GB) | 2021-02-25 | — | — | US | disclosed |
| US-20210052554-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS PHARMACEUTICALS UK LIMITED (GB) | 2021-02-25 | — | — | US | disclosed |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| US-4442202-A | SILVER HALIDE, REDOX SYSTEM, ORGANOBROMINE COMPOUND, STORAGE STABILITY | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-04-10 | — | — | US | disclosed |
| US-4396712-A | ORGANIC SILVER SALT OXIDIZER, REDUCING AGENT, SILVER HALIDE OR SILVER HALIDE FORMER, TONER, BINDER, HYDROXYPHENYLBENZOTRIAZOLE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1983-08-02 | — | — | US | disclosed |
| US-4332889-A | IMPROVED SENSITIVITY, STORAGE STABILITY | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1982-06-01 | — | — | US | disclosed |
| US-4268626-A | Dry image forming material | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-05-19 | — | — | US | disclosed |
| US-4115096-A | Dihydropyrazolone herbicide | FMC CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210052554-A1 | CARBOXAMIDE DERIVATIVES | SIRT5, SIRT7, ADCY5 | ALDH1A1 350/4885POLB 3845/4885KMT2A 683/4885 |
| US-20230301970-A1 | CARBOXAMIDE DERIVATIVES | SIRT1, ADCY5, ASIC1 | ALDH1A1 183/4885POLB 4028/4885KMT2A 733/4885 |
| US-11672782-B2 | Carboxamide derivatives | SIRT5, SIRT7, ADCY5 | ALDH1A1 350/4885POLB 3845/4885KMT2A 683/4885 |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | GRIN1, GRM1, GRIN3A | ALDH1A1 1785/4885POLB 4059/4885KMT2A 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.