SCHEMBL4318918

SCHEMBL4318918

CO[Si](CCCSc1ncccn1)(OC)OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.58
NPC1 O15118 8/20 0.58
SMN1; SMN2 Q16637 6/20 0.58
MAPT P10636 4/20 0.58
HSD17B10 Q99714 2/20 0.58
ALDH1A1 P00352 2/20 0.58
MAPK1 P28482 3/20 0.53
ALOX15 P16050 1/20 0.53
TSHR P16473 1/20 0.53
TP53 P04637 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
HTT P42858 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
RECQL P46063 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10884246 0.80 RAB9A (0.50) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL18227294 0.78 NPC1 (0.50) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL17726985 0.77 SMN1; SMN2 (0.36) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL4325251 0.77 ALDH1A1 (0.58) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL18238949 0.76 NPC1 (0.47) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL11757581 0.74 ALDH1A1 (0.50) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL423622 0.74 SMN1; SMN2 (0.57) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL9435490 0.74 SMN1; SMN2 (0.57) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL2884012 0.73 FDPS (0.45) RAB9ANPC1SMN1; SMN2MAPTHSD17B10
SCHEMBL7049219 0.72 SMN1; SMN2 (0.53) RAB9ANPC1SMN1; SMN2MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1713794-B1 HETEROCYCLE GRAFTED MONOMERS AND RELATED POLYMERS AND HYBRID INORGANIC-ORGANIC POLYMER MEMBRANES TOYOTA TECHNICAL CT U S A INC (US) 2014-05-07 EP disclosed
US-7576165-B2 Having an acid group attached to the hybrid inorganic-organic matrix; and a nitrogen-containing heterocycle attached to the hybrid inorganic-organic matrix, wherein the nitrogen-containing heterocycle is selected from 1,2,4-triazole,1,2,3-triazole, 1H-benzotriazole, pyrimidine, for example; fuel cells GEORGIA INSTITUTE OF TECHNOLOGY (US) 2009-08-18 US disclosed
US-7576165-B2 Having an acid group attached to the hybrid inorganic-organic matrix; and a nitrogen-containing heterocycle attached to the hybrid inorganic-organic matrix, wherein the nitrogen-containing heterocycle is selected from 1,2,4-triazole,1,2,3-triazole, 1H-benzotriazole, pyrimidine, for example; fuel cells GEORGIA INSTITUTE OF TECHNOLOGY (US) 2009-08-18 US disclosed
EP-1713794-A2 HETEROCYCLE GRAFTED MONOMERS AND RELATED POLYMERS AND HYBRID INORGANIC-ORGANIC POLYMER MEMBRANES Toyota Technical Center, U.S.A., Inc. (US) 2006-10-25 EP disclosed
US-20060111530-A1 Heterocycle grafted monomers and related polymers and hybrid inorganic-organic polymer membranes TOYOTA MOTOR CORPORATION (JP) 2006-05-25 US disclosed
WO-2005072413-A2 HETEROCYCLE GRAFTED MONOMERS AND RELATED POLYMERS AND HYBRID INORGANIC-ORGANIC POLYMER MEMBRANES TOYOTA TECHNICAL CENTER, USA, INC. (US) 2005-08-11 WO disclosed