Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31542005 | 1.00 | HSD17B10 (0.53) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL10352528 | 0.81 | HSD17B10 (0.50) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL28768922 | 0.77 | HSD17B10 (0.53) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL11034753 | 0.77 | HSD17B10 (0.61) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL9024189 | 0.77 | HSD17B10 (0.53) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL24125191 | 0.77 | CREBBP (0.57) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL2745305 | 0.77 | CREBBP (0.57) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL10729385 | 0.77 | HSD17B10 (0.65) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL3626456 | 0.74 | CA2 (0.62) | HSD17B10KDM4ETDP1POLBALOX15 | |
| SCHEMBL4969852 | 0.74 | MAPT (0.51) | HSD17B10KDM4ETDP1POLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579363-B2 | Bicyclic compounds and compositions as PDF inhibitors | IRM LLC (BM) | 2009-08-25 | — | — | US | disclosed |
| EP-1651643-A4 | BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS | IRM LLC (BM) | 2008-10-08 | — | — | EP | disclosed |
| US-20070259852-A1 | BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS | IRM LLC | 2007-11-08 | — | — | US | disclosed |
| US-7253164-B2 | Bicyclic compounds and compositions as PDF inhibitors | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| EP-1651643-A2 | BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS | IRM, LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| US-20050197326-A1 | Bicyclic compounds and compostions as PDF inhibitors | IRM LLC | 2005-09-08 | — | — | US | disclosed |
| WO-2005011611-A2 | BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS | IRM, LLC (BM) | 2005-02-10 | — | — | WO | disclosed |
| CN-1033584-C | Benzo-fused lactams that promote release of growth hormone | MERCK & CO INC (US) | 1996-12-18 | — | — | CN | disclosed |
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0441539-B1 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO (JP) | 1996-04-10 | — | — | EP | disclosed |
| US-5281592-A | Calcium antagonist, antiischemic agents, brains, nervous system disorders | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5246929-A | Prophylaxis or treatment of ischemic encephalopathia | TANABE SEIYAKU CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0488008-A1 | Heterocyclic substituted piperazinoalkylbenzoxazine and -thiazine compounds, process for their preparation and therapeutic drugs containing them | Kali-Chemie Pharma GmbH (DE) | 1992-06-03 | — | — | EP | disclosed |
| EP-0488009-A2 | Piperidinoalkyl-benzoxazine-and-thiazine-compounds, processes for their preparation and drugs containing them | Kali-Chemie Pharma GmbH (DE) | 1992-06-03 | — | — | EP | disclosed |
| EP-0441539-A2 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197326-A1 | Bicyclic compounds and compostions as PDF inhibitors | PDF, FDPS, DCTPP1 | HSD17B10 2730/4885KDM4E 1224/4885TDP1 124/4885 |
| US-20070259852-A1 | BICYCLIC COMPOUNDS AND COMPOSITIONS AS PDF INHIBITORS | PDF, FDPS, DCTPP1 | HSD17B10 1950/4885KDM4E 1204/4885TDP1 1137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.