Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13578027 | 0.89 | HTR1A (0.42) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4330789 | 0.88 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2TBXAS1LMNA | |
| SCHEMBL4326720 | 0.85 | DRD3 (0.47) | PTAFRNPC1RAB9ALMNAHTR1A | |
| SCHEMBL4328379 | 0.85 | NPC1 (0.47) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4320035 | 0.83 | LMNA (0.44) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4330823 | 0.81 | RAB9A (0.43) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4334076 | 0.81 | NPC1 (0.43) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4338927 | 0.80 | LMNA (0.43) | PTAFRNPC1RAB9ASMN1; SMN2TBXAS1 | |
| SCHEMBL4335986 | 0.80 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TBXAS1LMNA | |
| SCHEMBL4340863 | 0.80 | PTAFR (0.42) | PTAFRNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |