Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | LPL | P06858 | 5/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRE | P78334 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29730121 | 0.82 | LPL (0.46) | NOS3NOS2LPLLIPGDGAT1 | |
| SCHEMBL183601 | 0.82 | LPL (0.46) | NOS3NOS2LPLLIPGDGAT1 | |
| SCHEMBL16278109 | 0.82 | LPL (0.46) | NOS3NOS2LPLLIPGDGAT1 | |
| SCHEMBL18631834 | 0.73 | DGAT1 (0.36) | LPLLIPGDGAT1 | |
| SCHEMBL32689814 | 0.71 | ELANE (0.39) | LPLLIPGSMN1; SMN2 | |
| SCHEMBL8074045 | 0.71 | NOS3 (0.34) | NOS3NOS2 | |
| SCHEMBL15661734 | 0.70 | LIPG (0.57) | LPLLIPGDGAT1PIK3CDF11 | |
| SCHEMBL18071 | 0.68 | CA1 (0.47) | LPLLIPGKDM4E | |
| SCHEMBL7954286 | 0.66 | DGAT1 (0.54) | LPLLIPGDGAT1F11 | |
| SCHEMBL24092802 | 0.66 | NOS3 (0.35) | NOS3NOS2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |