Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.39 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.39 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.39 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.39 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.39 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.39 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330789 | 0.85 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4328379 | 0.83 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4330823 | 0.82 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4338927 | 0.82 | LMNA (0.43) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4332243 | 0.81 | PTAFR (0.45) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4320035 | 0.79 | LMNA (0.44) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4335986 | 0.78 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNATBXAS1 | |
| SCHEMBL4340863 | 0.78 | PTAFR (0.42) | NPC1RAB9ASMN1; SMN2LMNADRD3 | |
| SCHEMBL4333849 | 0.75 | DRD2 (0.46) | SMN1; SMN2DRD3DRD2 | |
| SCHEMBL4320012 | 0.75 | LMNA (0.46) | NPC1RAB9ALMNADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |