Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.37 |
| ▸ | PPARA | Q07869 | 9/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330640 | 1.00 | PPARG (0.37) | PPARGPPARAPPARDACEKDM4E | |
| SCHEMBL4381546 | 0.79 | GPR119 (0.35) | KDM4EMAPTSLC6A4 | |
| SCHEMBL4381548 | 0.79 | GPR119 (0.35) | KDM4EMAPTSLC6A4 | |
| SCHEMBL3989548 | 0.78 | KMT2A (0.40) | MAPT | |
| SCHEMBL2791431 | 0.78 | SMN1; SMN2 (0.39) | NPC1MAPTRAB9A | |
| SCHEMBL2791434 | 0.78 | SMN1; SMN2 (0.39) | NPC1MAPTRAB9A | |
| SCHEMBL8539792 | 0.78 | SMN1; SMN2 (0.40) | RAB9A | |
| SCHEMBL4324062 | 0.77 | TRPM8 (0.40) | KDM4ENPC1MAPTRAB9A | |
| SCHEMBL4324066 | 0.77 | TRPM8 (0.40) | KDM4ENPC1MAPTRAB9A | |
| SCHEMBL4335628 | 0.75 | SLC7A5 (0.39) | HDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |