Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539792 | 0.84 | SMN1; SMN2 (0.40) | LMNAL3MBTL1 | |
| SCHEMBL4324062 | 0.80 | TRPM8 (0.40) | ALOX5NOX1MAOBLMNAL3MBTL1 | |
| SCHEMBL4324066 | 0.80 | TRPM8 (0.40) | ALOX5NOX1MAOBLMNAL3MBTL1 | |
| SCHEMBL8155343 | 0.80 | ALOX5 (0.46) | ALOX5NOX1LTA4HMAOBNR4A1 | |
| SCHEMBL3104540 | 0.78 | NOX1 (0.50) | ALOX5NOX1LTA4HMAOBLMNA | |
| SCHEMBL29633164 | 0.78 | MAOB (0.50) | ALOX5NOX1MAOBNR4A1NR4A2 | |
| SCHEMBL7447861 | 0.77 | MEN1 (0.40) | — | |
| SCHEMBL17890894 | 0.77 | NOX1 (0.54) | ALOX5NOX1LTA4HMAOBLMNA | |
| SCHEMBL2791431 | 0.76 | SMN1; SMN2 (0.39) | ALOX5LMNA | |
| SCHEMBL3989548 | 0.76 | KMT2A (0.40) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708085-B1 | Antiviral ethers of aspartate protease substrate isosteres | NOVARTIS AG (CH) | 2002-07-17 | — | — | EP | disclosed |
| US-5935976-A | Antiviral ethers of aspartate protease substrate isosteres | NOVARTIS CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
| US-5807891-A | RETROVIRUSES | NOVARTIS AG (CH) | 1998-09-15 | — | — | US | disclosed |
| US-5663200-A | CARBAMOYL PEPTIDE DERIVATIVES AS VIRICIDES | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0708085-A2 | Antiviral ethers of aspartate protease substrate isosteres | CIBA-GEIGY AG (CH) | 1996-04-24 | — | — | EP | disclosed |