Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336015 | 0.83 | NPC1 (0.41) | SMYD2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4320012 | 0.83 | LMNA (0.46) | SMYD2SCN9ASLC22A12CPT2CPT1A | |
| SCHEMBL4333849 | 0.83 | DRD2 (0.46) | SCN9ACPT2CPT1ACPT1B | |
| SCHEMBL4330789 | 0.81 | NPC1 (0.49) | PPARGSCN9ASLC22A12CPT2CPT1A | |
| SCHEMBL4324558 | 0.80 | NPC1 (0.48) | SMYD2SCN9ASLC22A12CPT2CPT1A | |
| SCHEMBL4321178 | 0.80 | LMNA (0.51) | PPARG | |
| SCHEMBL4327173 | 0.80 | SCN9A (0.39) | SMYD2PPARGCNR1SCN9ACPT2 | |
| SCHEMBL4336046 | 0.79 | LMNA (0.46) | PPARGSCN9A | |
| SCHEMBL4324640 | 0.79 | HCRTR1 (0.54) | CNR1SCN9A | |
| SCHEMBL4335709 | 0.79 | CYP2C19 (0.39) | SMYD2PPARGCNR1SCN9ACPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |