Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | PPOX | P50336 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL42961 | 0.98 | MRGPRX4 (0.45) | MRGPRX4SORT1DDR1HPGDKDM4E | |
| SCHEMBL42960 | 0.87 | DDR1 (0.44) | MRGPRX4SORT1DDR1HPGDALDH1A1 | |
| SCHEMBL9465476 | 0.84 | CASP1 (0.43) | MRGPRX4DDR1ALDH1A1GPR35CES2 | |
| SCHEMBL18243875 | 0.84 | DDR1 (0.45) | MRGPRX4DDR1ALDH1A1GPR35CES2 | |
| SCHEMBL1579735 | 0.83 | NPC1 (0.42) | MRGPRX4SORT1DDR1ALDH1A1GPR35 | |
| SCHEMBL2515684 | 0.83 | GPR35 (0.46) | MRGPRX4SORT1HPGDKDM4EALDH1A1 | |
| SCHEMBL9465832 | 0.81 | ALDH1A1 (0.46) | HPGDKDM4EALDH1A1HSD17B10RXRA | |
| SCHEMBL30451908 | 0.81 | ALDH1A1 (0.46) | HPGDKDM4EALDH1A1HSD17B10RXRA | |
| SCHEMBL23528905 | 0.81 | DDR1 (0.41) | MRGPRX4SORT1DDR1HPGDKDM4E | |
| SCHEMBL24973075 | 0.80 | MRGPRX4 (0.45) | MRGPRX4SORT1HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642802-B2 | Process for the preparation of halogenated benzoic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-02-04 | — | — | US | claimed |
| EP-2310349-B1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2013-04-24 | — | — | EP | claimed |
| US-20120330055-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | BACHMANN STEPHAN (CH) | 2012-12-27 | — | — | US | claimed |
| US-8329939-B2 | Process for the preparation of halogenated benzoic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | claimed |
| US-20120130121-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | BACHMANN STEPHAN (CH) | 2012-05-24 | — | — | US | claimed |
| CN-102056883-A | Process for the preparation of halogenated benzoic acid derivatives | HOFFMANN LA ROCHE | 2011-05-11 | — | — | CN | claimed |
| EP-2310349-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-04-20 | — | — | EP | claimed |
| US-20090306423-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-12-10 | — | — | US | claimed |
| WO-2009147068-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-10 | — | — | WO | claimed |
| JP-2178255-A | — | — | None | — | — | JP | disclosed |
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |
| US-20210093618-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-04-01 | — | — | US | disclosed |
| US-20200108054-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2020-04-09 | — | — | US | disclosed |
| CN-105793238-B | Substituted benzamides and methods of use thereof | 基因泰克公司 | 2019-12-24 | — | — | CN | disclosed |
| US-20070185058-A1 | Heteroaryl and benzyl amide compounds | HOFFMANN-LA ROCHE INC. | 2007-08-09 | — | — | US | disclosed |
| EP-1791810-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIA INHIBITORS | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| US-20060116410-A1 | 4-Aminomethyl benzamidine derivatives | HOFFMANN-LA ROCHE INC. | 2006-06-01 | — | — | US | disclosed |
| WO-2006027135-A1 | 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIIA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-16 | — | — | WO | disclosed |
| US-5196593-A | HALOGENATED TRIFLUOROMETHYLBENZENES | OCCIDENTAL CHEMICAL CORPORATION (US) | 1993-03-23 | — | — | US | disclosed |
| JP-H02178255-A | NOVEL HALOGENATED TRIFLUOROMETHYLBENZENE | OCCIDENTAL CHEM CORP | 1990-07-11 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306423-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | CYP2F1, CYP3A5, GABRA5 | MRGPRX4 3785/4885SORT1 3133/4885DDR1 4881/4885 |
| US-20120330055-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | CYP2F1, GABRA5, CYP3A5 | MRGPRX4 3786/4885SORT1 3317/4885DDR1 4882/4885 |
| US-20210093618-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | BRIX1, RDX, SULT2A1 | MRGPRX4 134/4885SORT1 3114/4885DDR1 3841/4885 |
| US-20070185058-A1 | Heteroaryl and benzyl amide compounds | CYP1B1, CYP4B1, ABCG2 | MRGPRX4 746/4885SORT1 3548/4885DDR1 3734/4885 |
| US-20120130121-A1 | PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES | CYP2F1, GABRA5, CYP3A5 | MRGPRX4 3786/4885SORT1 3317/4885DDR1 4882/4885 |
| US-20060116410-A1 | 4-Aminomethyl benzamidine derivatives | F7, HABP2, F12 | MRGPRX4 126/4885SORT1 4635/4885DDR1 1764/4885 |
| US-20200108054-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | BRIX1, RDX, SULT2A1 | MRGPRX4 134/4885SORT1 3114/4885DDR1 3841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.