Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336372 | 0.87 | HAO1 (0.39) | HAO1ALOX15NQO2PTGS1MAPT | |
| SCHEMBL4337764 | 0.81 | HSD17B10 (0.59) | HAO1ALOX15NQO2PTGS1HTT | |
| SCHEMBL4337657 | 0.80 | SLC6A9 (0.43) | HAO1NQO2PTGS1MAPTHTT | |
| SCHEMBL4338317 | 0.78 | ESR2 (0.49) | ALOX15MAPTHTTSLC6A9HPGD | |
| SCHEMBL4347570 | 0.77 | PTGS1 (0.40) | HAO1PTGS1MAPTSLC6A9MEN1 | |
| SCHEMBL4330280 | 0.77 | MAOA (0.38) | HAO1NQO2PTGS1SLC6A9CA2 | |
| SCHEMBL11316818 | 0.76 | ALOX15 (0.54) | ALOX15MAPTHTTHPGDMEN1 | |
| SCHEMBL4342646 | 0.74 | SLC6A9 (0.40) | HAO1PTGS1MAPTSLC6A9MEN1 | |
| SCHEMBL482240 | 0.72 | HAO1 (0.55) | HAO1CYP3A4CYP2D6CES2EPHX1 | |
| SCHEMBL4336068 | 0.71 | SLC6A9 (0.43) | HAO1ALOX15HTTSLC6A9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612068-B2 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2009-11-03 | — | — | US | disclosed |
| CN-100439330-C | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | LUNDBECK & CO AS H (DK) | 2008-12-03 | — | — | CN | disclosed |
| US-20060235003-A1 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| CN-1780815-A | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | LUNDBECK & CO AS H (DK) | 2006-05-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235003-A1 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives | TYR, TPST2, COMT | HAO1 1672/4885ALOX15 3338/4885NQO2 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.