Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23075577 | 0.76 | DRD2 (0.42) | ALDH1A1TSHRRPS6KB1ROCK1PTGS2 | |
| SCHEMBL29593075 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRHPGDKDM4EHTT | |
| SCHEMBL289737 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRHPGDKDM4EHTT | |
| SCHEMBL288756 | 0.72 | GAA (0.51) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL29370031 | 0.72 | GAA (0.51) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL23075579 | 0.71 | ALDH1A1 (0.59) | ALDH1A1TSHRAPLNRHPGDKDM4E | |
| SCHEMBL9263233 | 0.70 | SCN9A (0.51) | ALDH1A1TSHRAPLNRPTGS2MAPT | |
| SCHEMBL17212359 | 0.68 | ALDH1A1 (0.37) | ALDH1A1MAPTHPGDKDM4EHTT | |
| SCHEMBL28181208 | 0.68 | MGLL (0.47) | ALDH1A1MAPTHPGDKDM4EHTT | |
| SCHEMBL23075576 | 0.67 | NOD2 (0.55) | ALDH1A1APLNRMAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231595-B1 | PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS | AMGEN INC (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8183293-B2 | Phenyl acetic acid derivatives | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| CN-101903338-A | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC | 2010-12-01 | — | — | CN | disclosed |
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | NFKBIA, HCAR2, NFATC1 | ALDH1A1 260/4885TSHR 4792/4885APLNR 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.