SCHEMBL434609

SCHEMBL434609

O=CO[CH]c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
CYP2A6 P11509 1/20 0.50
LMNA P02545 4/20 0.42
TRPA1 O75762 2/20 0.42
ALOX5 P09917 1/20 0.42
MAPK1 P28482 1/20 0.42
TSHR P16473 2/20 0.38
MAOB P27338 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.36
HDAC3 O15379 1/20 0.36
TNKS O95271 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6558335 0.83 ALDH1A1 (0.45) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL11244216 0.75 CYP2A6 (0.54) CYP2A6TSHRL3MBTL1CYP1A2MAPT
SCHEMBL173274 0.75 ALDH1A1 (0.50) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL12298544 0.75 ALDH1A1 (0.50) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL9444804 0.74 ALDH1A1 (0.50) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL6932980 0.74 ALDH1A1 (0.38) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL11561538 0.73 ALDH1A1 (0.37) ALDH1A1CYP2A6LMNASMN1; SMN2
Ammonia Solution, Strong SCHEMBL17394609 0.73 ALDH1A1 (0.48) ALDH1A1CYP2A6LMNATRPA1ALOX5
SCHEMBL9491570 0.72 MAOB (0.48) ALDH1A1LMNATRPA1ALOX5MAPK1
Styrene SCHEMBL28883543 0.72 ALDH1A1 (0.61) ALDH1A1CYP2A6LMNATRPA1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515972-B1 AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY HOFFMANN LA ROCHE (CH) 2009-05-13 EP claimed
US-7135475-B2 Antidiabetic agents HOFFMANN-LA ROCHE INC. (US) 2006-11-14 US claimed
EP-1515972-A1 AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2005-03-23 EP claimed
US-20040014766-A1 Amide substituted xanthine derivatives HOFFMANN-LA ROCHE INC. 2004-01-22 US claimed
WO-2003106459-A1 AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY F. HOFFMANN-LA ROCHE AG (CH) 2003-12-24 WO claimed
US-6054303-A CYCLOSPORINS CONJUGATED AT AN ALANINE NITROGEN ATOM TO AN IMMUNOGENIC CARRIER, A LIGAND, A SMALL ORGANIC COMPOUND OR A LABEL THROUGH A LINKER OF ALKYLENE OXIDE CHAIN OR CARBONYLOXYBENZYL GROUP INCLUDING 1-3 CARBOXAMIDE GROUPS DADE BEHRING MARBURG GMBH (DE) 2000-04-25 US claimed
US-5807984-A CONTROLLING DISEASES; PENTAPEPTIDES BASF AKTIENEGESELLSCHAFT (DE) 1998-09-15 US claimed
EP-0859786-A1 PEPTIDE DERIVATIVES OF DOLASTATIN 15 AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 1998-08-26 EP claimed
WO-1997017364-A1 PEPTIDE DERIVATIVES OF DOLASTATIN 15 AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 1997-05-15 WO claimed
US-11975290-B2 Cyclopropeneimines for capture and transfer of carbon dioxide INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2024-05-07 US disclosed
US-11890531-B2 Maintenance method of bowling ball, plasticizer YAMADA YUTAKA (JP) 2024-02-06 US disclosed
US-11878269-B2 Cyclopropeneimines for capture and transfer of carbon dioxide INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2024-01-23 US disclosed
US-20230294041-A1 CYCLOPROPENEIMINES FOR CAPTURE AND TRANSFER OF CARBON DIOXIDE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-09-21 US disclosed
US-20230294042-A1 CYCLOPROPENEIMINES FOR CAPTURE AND TRANSFER OF CARBON DIOXIDE THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-09-21 US disclosed
US-4468514-A Preparation of 3-bromocephalosporins from thiazoline azetidinones ELI LILLY AND COMPANY (US) 1984-08-28 US disclosed
EP-0112135-A2 Bromination of cephalosporins ELI LILLY AND COMPANY (US) 1984-06-27 EP disclosed
EP-0011370-B1 PROCESS FOR PREPARING 2-CHLOROSULFINYL-AZETIDINONES ELI LILLY AND COMPANY (US) 1982-04-28 EP disclosed
US-4289695-A REACTION OF A PHENICILLIN WITH AN N-CHLORO HALOGENATING AGENT IN PRESENCE OF A CROSSLINKED POLYVINYLPYRIDINE ELI LILLY AND COMPANY (US) 1981-09-15 US disclosed
EP-0011370-A1 Process for preparing 2-chlorosulfinyl-azetidinones ELI LILLY AND COMPANY (US) 1980-05-28 EP disclosed
US-4159272-A Process for 2-chlorosulfinylazetidin-4-ones ELI LILLY AND COMPANY (US) 1979-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014766-A1 Amide substituted xanthine derivatives GYS2, GLS2, PYGL ALDH1A1 297/4885CYP2A6 200/4885LMNA 4005/4885
US-11890531-B2 Maintenance method of bowling ball, plasticizer PHB2, VCL, PHB1 ALDH1A1 2968/4885CYP2A6 3096/4885LMNA 4483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.