Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6226369 | 0.89 | LMNA (0.48) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4342192 | 0.88 | MAPT (0.53) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4346975 | 0.87 | RAB9A (0.68) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4349474 | 0.86 | EPHX1 (0.58) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4354098 | 0.83 | ALDH1A1 (0.47) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4344567 | 0.82 | ALDH1A1 (0.57) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL27782816 | 0.81 | SMN1; SMN2 (0.52) | MAPTKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL4351418 | 0.80 | SMN1; SMN2 (0.48) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4345459 | 0.79 | MEN1 (0.46) | MAPTKMT2ASMN1; SMN2MEN1RAB9A | |
| SCHEMBL4351932 | 0.77 | KDM4E (0.41) | MAPTKMT2AMEN1MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |