Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584076 | 0.88 | AHR (0.35) | AHR | |
| SCHEMBL6806233 | 0.84 | — | — | |
| SCHEMBL9667405 | 0.83 | MAPK1 (0.39) | AHRCYP1A2CYP2A6MCL1TDP2 | |
| SCHEMBL2430752 | 0.83 | TXN (0.34) | MAOBCNR1TSHR | |
| SCHEMBL15287226 | 0.83 | AHR (0.31) | AHR | |
| SCHEMBL21143011 | 0.82 | TDP2 (0.41) | AHRTDP2 | |
| SCHEMBL246786 | 0.82 | CYP1A2 (0.42) | ALOX5CYP1A2LMNACYP2A6MCL1 | |
| SCHEMBL2050957 | 0.81 | CYP11B2 (0.37) | AHRNOTUM | |
| SCHEMBL27486807 | 0.80 | CYP1A2 (0.41) | ALOX5CYP1A2LMNACYP2A6MCL1 | |
| SCHEMBL693803 | 0.79 | ERCC1 (0.41) | AHRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-01-07 | — | — | US | claimed |
| EP-2119719-A1 | THIAZEPINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-11-18 | — | — | EP | claimed |
| US-9307767-B2 | Herbicidally and insecticidally active thiazolopyridinones | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-12 | — | — | US | disclosed |
| EP-2831084-B1 | HERBICIDAL AND INSECTICIDAL THIAZOLOPYRIDINONES | BAYER IP GMBH (DE) | 2016-03-23 | — | — | EP | disclosed |
| EP-2415763-B1 | PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA | UBE INDUSTRIES (JP) | 2016-01-27 | — | — | EP | disclosed |
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2015-02-12 | — | — | US | disclosed |
| EP-2831084-A1 | HERBICIDALLY AND INSECTICIDALLY ACTIVE THIAZOLOPYRIDINONES | Bayer Intellectual Property GmbH (DE) | 2015-02-04 | — | — | EP | disclosed |
| WO-2013144096-A1 | HERBICIDALLY AND INSECTICIDALLY ACTIVE THIAZOLOPYRIDINONES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-03 | — | — | WO | disclosed |
| EP-2595984-A1 | MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595985-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010568-A1 | MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012010567-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2119719-A1 | THIAZEPINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| US-4946493-A | FUNGICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-07 | — | — | US | disclosed |
| US-4845250-A | FUNGICIDES, PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-07-04 | — | — | US | disclosed |
| US-4507140-A | GALLIUM ARSENIDE DOPED WITH GERMANIUM AND TELLURIUM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-03-26 | — | — | US | disclosed |
| US-4501746-A | HERBICIDES; PLANT GROWTH REGULATORS | ELI LILLY AND COMPANY (US) | 1985-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | HSD11B1, HSD17B1, HSD3B1 | ALOX5 1933/4885AHR 1503/4885CYP1A2 104/4885 |
| US-20150045217-A1 | Herbicidally and Insecticidally Active Thiazolopyridinones | CBR3, DDT, CBR1 | ALOX5 3090/4885AHR 391/4885CYP1A2 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.