Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Acetophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.52 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CES2 | O00748 | 3/20 | 0.59 |
| ▸ | CES1 | P23141 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL8054906 | 1.00 | MAPT (0.68) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL27759678 | 0.97 | MAPT (0.65) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL27462873 | 0.97 | MAPT (0.71) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL30537005 | 0.97 | — | — | |
| Acetophenone SCHEMBL719033 | 0.97 | MAPT (0.71) | MAPTSMN1; SMN2HPGDALDH1A1LMNA | |
| Acetophenone SCHEMBL737 | 0.97 | — | — | |
| Acetophenone SCHEMBL16745259 | 0.97 | — | — | |
| Acetophenone SCHEMBL1450855 | 0.97 | — | — | |
| Acetophenone SCHEMBL30537000 | 0.97 | — | — | |
| Acetophenone SCHEMBL11876785 | 0.94 | MAPT (0.68) | MAPTSMN1; SMN2HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029236-A1 | METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND | L'Oreal (FR) | 2009-03-04 | — | — | EP | claimed |
| WO-2007135298-A1 | METHOD FOR STRAIGHTENING KERATINOUS FIBERS USING HEATING MEANS AND AN AROMATIC COMPOUND | L'OREAL (FR) | 2007-11-29 | — | — | WO | claimed |
| CN-117925654-A | Pseudomonas putida omega-aminotransferase gene with wide substrate spectrum and application thereof | 山西大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-219347024-U | Cooling device for acetophenone production | 海城利奇碳材有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-109937255-A | Original seed event EE-GH7 and method and kit for identifying the event in the biological sample | 巴斯夫农业种子解决方案美国有限责任公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-105745273-B | resin composition and cured product thereof | 株式会社大赛璐 | 2019-05-07 | — | — | CN | disclosed |
| CN-109400601-A | A kind of pyrazole derivatives and its preparation and use of pyrazolyl containing substitution | 海利尔药业集团股份有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-108503518-A | A kind of preparation and its application of compound sepiolite base catalyst | 湖南师范大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-107287234-A | The ways and means of modified plant genome | 拜尔作物科学公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-107250914-A | Upper layer film formation composition and the pattern formation method of the upper layer film formation composition and the manufacture method of electronic device are used | 富士胶片株式会社 | 2017-10-13 | — | — | CN | disclosed |
| EP-2862889-B1 | METHOD FOR PRODUCING SOLID POLYMETHYLALUMINOXANE COMPOSITION HAVING SMALL PARTICLE DIAMETER | TOSOH FINECHEM CORP (JP) | 2017-01-04 | — | — | EP | disclosed |
| CN-1286710-A | Method for producing polycarbonate | IDEMITSU KOSAN CO (JP) | 2001-03-07 | — | — | CN | disclosed |
| CN-1278076-A | Agent for lowering dependence of substrate | WAKO PURE CHEM IND LTD (JP) | 2000-12-27 | — | — | CN | disclosed |
| CN-1019571-B | Process for preparing biphenyl-n-propylamine derivatives and their salts | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1992-12-23 | — | — | CN | disclosed |
| US-4929677-A | MOLDING MATERIALS, POLYESTERS AND VINYL AROMATIC COMPOUNDS/N-PHENYL MALEIMIDE COPOLYMER BLENDS; IMPACT STRENGTH | ARCO CHEMICAL TECHNOLOGY, INC. (US) | 1990-05-29 | — | — | US | disclosed |
| CN-87108295-A | New alkane sulfonyl aniline derivative and its medicinal compositions and preparation method | — | 1988-07-13 | — | — | CN | disclosed |
| US-4160088-A | HALOGENATION OF KETONE, ALKANOL, HYDROLYSIS | GENERAL ELECTRIC COMPANY (US) | 1979-07-03 | — | — | US | disclosed |
| US-4158094-A | BLOWING AGENTS | GENERAL ELECTRIC COMPANY (US) | 1979-06-12 | — | — | US | disclosed |
| US-4152440-A | DIURETICS, ANALGESICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-01 | — | — | US | disclosed |
| US-4097671-A | 5-PHENYL-3,6-DIHYDRO-1,3,4-OXADIAZIN-2-ONE, THERMOPLASTIC POLYMER BLOWING AGENT | GENERAL ELECTRIC COMPANY (US) | 1978-06-27 | — | — | US | disclosed |