Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5654173 | 0.80 | KDM4E (0.44) | LMNAKDM4EALDH1A1HPGDMMP2 | |
| SCHEMBL4369490 | 0.80 | KDM4E (0.44) | POLBL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL2252337 | 0.79 | POLB (0.48) | POLBTDP1L3MBTL1CTDSP1APEX1 | |
| SCHEMBL5653527 | 0.79 | SMN1; SMN2 (0.47) | KDM4EALDH1A1HPGDMMP2MMP9 | |
| SCHEMBL5651555 | 0.78 | KDM4E (0.51) | L3MBTL1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL5651085 | 0.78 | RAB9A (0.43) | LMNAKDM4EMAPTMMP2MMP9 | |
| SCHEMBL4359340 | 0.78 | KDM4E (0.42) | POLBTDP1CTDSP1LMNAKDM4E | |
| SCHEMBL5655905 | 0.78 | KDM4E (0.42) | KDM4EMMP2MMP9KMT2AMEN1 | |
| SCHEMBL4365892 | 0.78 | KDM4E (0.42) | POLBKDM4EALDH1A1MMP2MMP9 | |
| SCHEMBL2247315 | 0.78 | KDM4E (0.46) | KDM4EMMP2MMP9SMN1; SMN2SLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | POLB 3997/4885TDP1 1018/4885L3MBTL1 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.