Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.37 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.36 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369490 | 0.87 | KDM4E (0.44) | KDM4EMMP2MMP9SLC1A5TLR2 | |
| SCHEMBL5653527 | 0.86 | SMN1; SMN2 (0.47) | KDM4EMMP2MMP9SLC1A5SMN1; SMN2 | |
| SCHEMBL5651085 | 0.84 | RAB9A (0.43) | KDM4EMMP2MMP9EPHX2NR1H4 | |
| SCHEMBL4365892 | 0.80 | KDM4E (0.42) | KDM4EMMP2MMP9SLC1A5SMN1; SMN2 | |
| SCHEMBL5655905 | 0.80 | KDM4E (0.42) | KDM4EMMP2MMP9SLC1A5HDAC1 | |
| SCHEMBL2251695 | 0.78 | SMN1; SMN2 (0.45) | KDM4EHDAC1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL5654173 | 0.78 | KDM4E (0.44) | KDM4EMMP2MMP9SLC1A5EPHX2 | |
| SCHEMBL4358335 | 0.78 | POLB (0.45) | KDM4EMMP2MMP9SLC1A5SMN1; SMN2 | |
| SCHEMBL4370877 | 0.77 | AOC3 (0.39) | KDM4EMMP2MMP9SLC1A5 | |
| SCHEMBL4361261 | 0.77 | MGLL (0.46) | KDM4EHDAC2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | KDM4E 1232/4885MMP2 49/4885MMP9 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.