Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369490 | 0.88 | KDM4E (0.44) | SMN1; SMN2KDM4EMAPK14NPC1RAB9A | |
| SCHEMBL5651085 | 0.86 | RAB9A (0.43) | KDM4ENPC1RAB9AMMP2MMP9 | |
| SCHEMBL4359340 | 0.86 | KDM4E (0.42) | SMN1; SMN2KDM4ENPC1RAB9AMMP2 | |
| SCHEMBL4365892 | 0.84 | KDM4E (0.42) | SMN1; SMN2KDM4ENPC1RAB9AMMP2 | |
| SCHEMBL5650385 | 0.84 | MAPT (0.42) | SMN1; SMN2KDM4EALDH1A1PPARGPPARA | |
| SCHEMBL5653113 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EOPRM1OPRD1OPRK1 | |
| SCHEMBL2251543 | 0.82 | FFAR1 (0.46) | OPRM1OPRD1OPRK1MAPK14MMP2 | |
| SCHEMBL5655905 | 0.82 | KDM4E (0.42) | SMN1; SMN2KDM4EMMP12MMP2MMP9 | |
| SCHEMBL2251695 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL5654173 | 0.80 | KDM4E (0.44) | SMN1; SMN2KDM4EMMP2MMP9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | SMN1; SMN2 2624/4885KDM4E 1232/4885OPRM1 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.