Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.57 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | DHFR | P00374 | 3/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362251 | 0.93 | APP (0.55) | APPDHFRTLR7TLR8ALDH1A1 | |
| SCHEMBL4367762 | 0.87 | APP (0.54) | APPBCHEACHEDHFRTLR7 | |
| SCHEMBL4074235 | 0.84 | NOS1 (0.48) | APPTLR7FYN | |
| SCHEMBL4357089 | 0.84 | APP (0.50) | APPDHFRCLK4KDM4E | |
| SCHEMBL4358329 | 0.81 | APP (0.59) | APPTLR7TLR8PDE5AKCNH2 | |
| SCHEMBL4355328 | 0.81 | APP (0.59) | APPTLR7TLR8PDE5A | |
| SCHEMBL4354805 | 0.81 | CLK4 (0.64) | APPCLK4ALDH1A1 | |
| SCHEMBL4358891 | 0.80 | ACHE (0.62) | APPBCHEACHECLK4PDE5A | |
| SCHEMBL4351984 | 0.79 | NSD2 (0.56) | APPBCHEACHEDHFRCLK4 | |
| SCHEMBL4362768 | 0.78 | DHFR (0.69) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12049461-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2024-07-30 | — | — | US | claimed |
| US-20210276988-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. | 2021-09-09 | — | — | US | claimed |
| US-10882851-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2021-01-05 | — | — | US | claimed |
| US-20160257673-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. | 2016-09-08 | — | — | US | claimed |
| US-9259426-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2016-02-16 | — | — | US | claimed |
| US-20090285782-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2009-11-19 | — | — | US | claimed |
| US-12049461-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2024-07-30 | — | — | US | disclosed |
| US-20240134300-A1 | TONER | CANON KABUSHIKI KAISHA (JP) | 2024-04-25 | — | — | US | disclosed |
| CN-111630456-B | White toner | 佳能株式会社 | 2024-04-16 | — | — | CN | disclosed |
| CN-117850181-A | Toner and method for producing the same | 佳能株式会社 | 2024-04-09 | — | — | CN | disclosed |
| US-20240067593-A1 | PRODUCTION OF AROMATIC ACIDS AND PHENOLICS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2024-02-29 | — | — | US | disclosed |
| EP-4048652-B1 | PRODUCTION OF AROMATIC ACIDS AND PHENOLICS | TNO (NL) | 2023-10-04 | — | — | EP | disclosed |
| US-20230088424-A1 | TONER PROCESSING APPARATUS AND METHOD FOR PRODUCING TONER | CANON KABUSHIKI KAISHA (JP) | 2023-03-23 | — | — | US | disclosed |
| US-6232277-B1 | ETHYLENE POLYMER; CONDENSATION PRODUCT OF ALDEHYDE OR KETONE WITH HYDROXY-, ALKOXY-, MERCAPTO-AND/OR ALKYLTHIO-SUBSTITUTED ALKYLARYL COMPOUND; AND POLAR NITROGEN COMPOUND; COLD FLOW, FILTERABILITY | EXXON CHEMICAL PATENTS INC | 2001-05-15 | — | — | US | disclosed |
| EP-1088013-A1 | ADDITIVES AND OIL COMPOSITIONS | Infineum USA L.P. (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1088045-A1 | ADDITIVES AND OIL COMPOSITIONS | Infineum USA L.P. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999061562-A1 | ADDITIVES AND OIL COMPOSITIONS | INFINEUM USA L.P. (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999061498-A1 | ADDITIVES AND OIL COMPOSITIONS | INFINEUM USA L.P. (US) | 1999-12-02 | — | — | WO | disclosed |
| US-4606947-A | HYDROXYL CONTAINING POLYESTER AND POLYISOCYANATE BLOCKED WITH ACETOACETIC ACID ALKYL ESTER | HERBERTS GMBH (DE) | 1986-08-19 | — | — | US | disclosed |
| US-4367295-A | POLYURETHANES | BAYER AKTIENGESELLSCHAFT (DE) | 1983-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12049461-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | NR3C1, NR3C2, NR4A1 | APP 4361/4885BCHE 4599/4885ACHE 4515/4885 |
| US-20210276988-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | NR3C1, NR3C2, NR4A1 | APP 4361/4885BCHE 4599/4885ACHE 4515/4885 |
| US-20240067593-A1 | PRODUCTION OF AROMATIC ACIDS AND PHENOLICS | DDC, PAH, FDPS | APP 895/4885BCHE 4019/4885ACHE 1252/4885 |
| US-20090285782-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | NR3C1, NR5A2, NR4A1 | APP 4235/4885BCHE 4565/4885ACHE 4468/4885 |
| US-10882851-B2 | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections | NR3C1, NR3C2, NR5A2 | APP 4318/4885BCHE 4694/4885ACHE 4535/4885 |
| US-20160257673-A1 | 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | NR3C1, NR3C2, NR5A2 | APP 4318/4885BCHE 4694/4885ACHE 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.