Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348250 | 0.86 | LMNA (0.39) | HRH4ALDH1A1LMNAMAPTHTT | |
| SCHEMBL4350354 | 0.85 | MPO (0.38) | HRH4HRH3ALDH1A1HTR3A | |
| SCHEMBL4352227 | 0.85 | HRH4 (0.35) | HRH4HRH3ALDH1A1LMNAHTT | |
| SCHEMBL4356646 | 0.85 | HRH4 (0.45) | HRH4LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL4355101 | 0.83 | ALDH1A1 (0.38) | HRH4HRH3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4103942 | 0.81 | KCNH2 (0.40) | HRH4 | |
| SCHEMBL4353639 | 0.81 | KDM4E (0.40) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL4354354 | 0.80 | HRH4 (0.44) | HRH4HRH3ALDH1A1 | |
| SCHEMBL4354372 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2POLB | |
| SCHEMBL4344619 | 0.75 | PARP1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |