Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348250 | 0.86 | LMNA (0.39) | HRH4HTTMEN1POLBKMT2A | |
| SCHEMBL4350354 | 0.85 | MPO (0.38) | HRH4HRH3SLC6A4KMT2AALDH1A1 | |
| SCHEMBL4356635 | 0.85 | HRH4 (0.47) | HRH4HRH3HTTPOLBALDH1A1 | |
| SCHEMBL4355101 | 0.83 | ALDH1A1 (0.38) | HRH4HRH3MEN1POLBKMT2A | |
| SCHEMBL4353639 | 0.81 | KDM4E (0.40) | HTTMEN1POLBKMT2AALDH1A1 | |
| SCHEMBL4356646 | 0.80 | HRH4 (0.45) | HRH4HTTHCRTR1HCRTR2LMNA | |
| SCHEMBL4354354 | 0.80 | HRH4 (0.44) | HRH4HRH3ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL4354372 | 0.78 | ALDH1A1 (0.42) | HTTPOLBKMT2AALDH1A1LMNA | |
| SCHEMBL4103942 | 0.77 | KCNH2 (0.40) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL4350617 | 0.73 | HCRTR1 (0.38) | HRH4HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |