Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 11/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103942 | 0.91 | KCNH2 (0.40) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL4353639 | 0.85 | KDM4E (0.40) | GAAHTTKDM4ELMNAMAPT | |
| SCHEMBL4356635 | 0.85 | HRH4 (0.47) | HRH4GAAHTTLMNAMAPT | |
| SCHEMBL4354354 | 0.84 | HRH4 (0.44) | HRH4PRCPKDM4ECYP1A2CYP3A4 | |
| SCHEMBL4109197 | 0.83 | TXN (0.36) | HRH4CACNA1GCACNA1HPRCPHCRTR1 | |
| SCHEMBL4348250 | 0.81 | LMNA (0.39) | HRH4HTTKDM4ELMNAMAPT | |
| SCHEMBL4352227 | 0.80 | HRH4 (0.35) | HRH4HTTLMNAHCRTR1HCRTR2 | |
| SCHEMBL4350354 | 0.80 | MPO (0.38) | HRH4KDM4EHCRTR1HCRTR2 | |
| SCHEMBL4355101 | 0.78 | ALDH1A1 (0.38) | HRH4GAAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL4344619 | 0.77 | PARP1 (0.42) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504426-B2 | Heterocyclic compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-17 | — | — | US | disclosed |