Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362689 | 0.81 | POLB (0.48) | POLBLMNAPKMHTTMAPT | |
| SCHEMBL3908386 | 0.79 | HSD17B2 (0.50) | NR3C1ARPGRESR2HIF1A | |
| SCHEMBL4370085 | 0.78 | ALOX15 (0.42) | HIF1APOLBLMNAPKMHTT | |
| SCHEMBL3909496 | 0.77 | HSD17B2 (0.49) | NR3C1ARPGRESR2HIF1A | |
| SCHEMBL4363789 | 0.76 | ALDH1A1 (0.53) | HSD17B2POLBLMNAHTTMAPT | |
| SCHEMBL1807440 | 0.75 | NR3C1 (0.51) | NR3C1ARPGRESR2HIF1A | |
| SCHEMBL3917148 | 0.73 | NR3C1 (0.48) | NR3C1ARPGRESR2HIF1A | |
| SCHEMBL27180227 | 0.72 | POLB (0.60) | NR3C1ARPGRESR2POLB | |
| SCHEMBL27678794 | 0.72 | HDAC1 (0.50) | NR3C1ARPGRESR2HIF1A | |
| SCHEMBL1821354 | 0.71 | BRD4 (0.59) | PGRHSD17B2MAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |