Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362689 | 0.88 | POLB (0.48) | ALDH1A1LMNAMEN1KMT2AHTT | |
| SCHEMBL4370085 | 0.87 | ALOX15 (0.42) | ALDH1A1LMNAMEN1KMT2AHTT | |
| SCHEMBL4359570 | 0.76 | NR3C1 (0.48) | ALDH1A1LMNAMEN1KMT2AHTR6 | |
| SCHEMBL1811576 | 0.75 | HSD17B1 (0.47) | LMNAMEN1KMT2AHTR6HSD17B1 | |
| SCHEMBL3917146 | 0.73 | HSD17B1 (0.45) | LMNAMEN1KMT2AHTR6HSD17B1 | |
| SCHEMBL5615200 | 0.72 | GSPT1 (0.47) | LMNAMEN1KMT2AHTR6MAPT | |
| SCHEMBL3903960 | 0.70 | LMNA (0.42) | LMNAMEN1KMT2AHTR6HSD17B1 | |
| SCHEMBL24876039 | 0.69 | MEN1 (0.72) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL3913044 | 0.69 | BRD4 (0.46) | — | |
| SCHEMBL24876052 | 0.69 | LMNA (0.64) | ALDH1A1LMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |