Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363789 | 0.88 | ALDH1A1 (0.53) | POLBMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4370085 | 0.83 | ALOX15 (0.42) | POLBMAPTLMNAPKMHTT | |
| SCHEMBL4359570 | 0.81 | NR3C1 (0.48) | POLBMAPTLMNAPKMHTT | |
| SCHEMBL3909458 | 0.76 | PKM (0.51) | MAPTLMNAPKMHTTSMN1; SMN2 | |
| SCHEMBL1843607 | 0.75 | PKM (0.50) | MAPTLMNAPKMSMN1; SMN2MEN1 | |
| SCHEMBL1809299 | 0.74 | PTGDR2 (0.47) | MAPTLMNAPKMHTTSMN1; SMN2 | |
| SCHEMBL3907941 | 0.73 | PKM (0.48) | MAPTLMNAPKMSMN1; SMN2MEN1 | |
| SCHEMBL5615200 | 0.69 | GSPT1 (0.47) | MAPTLMNAPKMMEN1KMT2A | |
| SCHEMBL1809464 | 0.68 | PTGDR2 (0.49) | POLBMAPTLMNAPKMHTT | |
| SCHEMBL1821354 | 0.67 | BRD4 (0.59) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |