Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615200 | 0.87 | GSPT1 (0.47) | MAPTMEN1KMT2AHIF1ALMNA | |
| SCHEMBL4363789 | 0.87 | ALDH1A1 (0.53) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL4362689 | 0.83 | POLB (0.48) | ALOX15ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL3906958 | 0.80 | LMNA (0.46) | ALDH1A1MAPTMEN1KMT2AHIF1A | |
| SCHEMBL4359570 | 0.78 | NR3C1 (0.48) | ALOX15ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL3917157 | 0.76 | GSPT1 (0.42) | ALDH1A1MAPTMEN1KMT2AHIF1A | |
| SCHEMBL3903016 | 0.76 | NR1I2 (0.48) | ALDH1A1MAPTMEN1KMT2AHIF1A | |
| SCHEMBL1811055 | 0.76 | GSPT1 (0.45) | ALDH1A1MAPTMEN1KMT2AHIF1A | |
| SCHEMBL3913044 | 0.76 | BRD4 (0.46) | NR1I2BRD4 | |
| SCHEMBL3906772 | 0.75 | GSPT1 (0.43) | ALDH1A1MAPTMEN1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |