SCHEMBL4361027

SCHEMBL4361027

ClCCC[SiH2]C(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 1/20 0.39
PPARG P37231 2/20 0.34
PPARA Q07869 2/20 0.34
ALDH1A1 P00352 3/20 0.33
DRD2 P14416 2/20 0.33
DRD3 P35462 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TSHR P16473 2/20 0.33
KCNH2 Q12809 2/20 0.33
SLC22A2 O15244 1/20 0.33
SLC22A1 O15245 1/20 0.33
SLC22A3 O75751 1/20 0.33
ESR1 P03372 1/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
CHRM1 P11229 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704372 0.88 KCNA3 (0.39) KCNA3PPARGPPARAALDH1A1DRD2
SCHEMBL705385 0.88 KCNA3 (0.39) KCNA3PPARGPPARAALDH1A1DRD2
SCHEMBL705838 0.84 LTA4H (0.38) KCNA3PPARGPPARAALDH1A1TSHR
SCHEMBL3815419 0.83 TAAR1 (0.41) KCNA3HTR2AHRH1LTA4HTAAR1
SCHEMBL4363261 0.81 KCNA3 (0.34) KCNA3TSHRTDP1LTA4HSLC6A4
SCHEMBL4354696 0.80 LTA4H (0.35) KCNA3PPARGPPARAALDH1A1TSHR
SCHEMBL704602 0.76 LTA4H (0.38) KCNA3PPARGPPARAALDH1A1TSHR
SCHEMBL4363429 0.72 KCNA3 (0.39) KCNA3PPARGPPARAALDH1A1TSHR
SCHEMBL4074158 0.71 TSHR (0.36) SMN1; SMN2TSHRHTR2AHRH1SCN4A
SCHEMBL11350510 0.70 LMNA (0.41) KCNA3PPARGPPARAALDH1A1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-6815554-B2 REACTING A HALOALKYLSILANE WITH A SALT OF AN UNSATURATED CARBOXYLIC ACID IN THE PRESENCE OF A PHASE TRANSFER CATALYST; BONDING AGENTS WACKER-CHEMIE GMBH (DE) 2004-11-09 US disclosed
US-20020151736-A1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER-CHEMIE GMBH (DE) 2002-10-17 US disclosed