SCHEMBL4074158

SCHEMBL4074158

ClCCC[SiH2]C(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.34
HTR2A P28223 4/20 0.33
HRH1 P35367 4/20 0.33
TAAR1 Q96RJ0 2/20 0.33
POLB P06746 1/20 0.33
MTOR P42345 1/20 0.31
RAB9A P51151 1/20 0.31
GRM7 Q14831 1/20 0.31
DPP4 P27487 2/20 0.31
F2 P00734 1/20 0.31
GRIN1 Q05586 2/20 0.31
GRIN2A Q12879 2/20 0.31
SCN4A P35499 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27842300 0.81 HRH1 (0.54) TSHRHTR2AHRH1TAAR1DPP4
SCHEMBL4660217 0.79 ALDH1A1 (0.40) HTR2AHRH1TAAR1
SCHEMBL4194601 0.79 HDAC3 (0.35) HTR2AHRH1TAAR1MTORRAB9A
SCHEMBL1645203 0.78 TSHR (0.42) TSHRHTR2AHRH1TAAR1MTOR
SCHEMBL3454935 0.74 TRPA1 (0.38) HTR2AHRH1TAAR1MTORRAB9A
SCHEMBL1270652 0.72 TAAR1 (0.42) TSHRHTR2AHRH1TAAR1MTOR
SCHEMBL4661596 0.71 HTT (0.32) TSHRSMN1; SMN2HTR2AHRH1
SCHEMBL4361027 0.71 KCNA3 (0.39) TSHRSMN1; SMN2HTR2AHRH1TAAR1
SCHEMBL9339406 0.69 TAAR1 (0.50) TSHRHTR2AHRH1TAAR1DPP4
SCHEMBL2118480 0.69 TAAR1 (0.39) TSHRHTR2AHRH1TAAR1MTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326936-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM MAXTERIAL INC (US) 2025-10-23 US disclosed
US-12173166-B2 Articles including surface coatings and methods to produce them MAXTERIAL, INC. (US) 2024-12-24 US disclosed
US-20230295827-A1 COATINGS AND COATED SURFACES INCLUDING LOW-SURFACE ENERGY INORGANIC PARTICLES MAXTERIAL INC (US) 2023-09-21 US disclosed
US-11542621-B1 Coatings and coated surfaces including low-surface energy inorganic particles MAXTERIAL, INC. (US) 2023-01-03 US disclosed
EP-3691894-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM Maxterial, Inc. (US) 2020-08-12 EP disclosed
CN-111405980-A Article comprising a surface coating and method for producing the same 麦克斯特里尔有限公司 2020-07-10 CN disclosed
US-20190186035-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM MAXTERIAL INC (US) 2019-06-20 US disclosed
WO-2019067950-A1 ARTICLES INCLUDING SURFACE COATINGS AND METHODS TO PRODUCE THEM MAXTERIAL, INC. (US) 2019-04-04 WO disclosed
US-20180028029-A1 DRYING APPARATUS COMPRISING A HYDROPHOBIC MATERIAL HAGHDOOST ATIEH (US) 2018-02-01 US disclosed
US-20170334170-A1 ARTICLES INCLUDING ADHESION ENHANCING COATINGS AND METHODS OF PRODUCING THEM HAGHDOOST ATIEH (US) 2017-11-23 US disclosed
US-20170190139-A1 COATINGS AND COATED SURFACES WITH SELECTED SURFACE CHARACTERISTICS AND FEATURES HAGHDOOST ATIEH (US) 2017-07-06 US disclosed
US-20090054369-A1 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS RND PHARMACEUTICALS, INC. (US) 2009-02-26 US disclosed
EP-1919929-A4 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS RND PHARMACEUTICALS INC (US) 2008-08-06 EP disclosed
EP-1919929-A2 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS RND Pharmaceuticals, Inc. (US) 2008-05-14 EP disclosed
WO-2007019221-A2 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS RND PHARMACEUTICALS, INC. (US) 2007-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054369-A1 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS SI, SLC29A2, SLC29A1 TSHR 3201/4885SMN1; SMN2 259/4885HTR2A 1991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.