Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.38 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | RGS4 | P49798 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4364853 | 1.00 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AKIF11KIF23 | |
| SCHEMBL4363445 | 0.88 | PDE1C (0.39) | ALDH1A1MEN1KMT2AKIF11KIF23 | |
| SCHEMBL4363455 | 0.85 | KDM4E (0.38) | ALDH1A1MEN1KMT2AKIF11KIF23 | |
| SCHEMBL4519535 | 0.83 | KIF11 (0.53) | ALDH1A1MEN1KMT2AKIF11CYP2C19 | |
| SCHEMBL4499166 | 0.83 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AADORA3RGS4 | |
| SCHEMBL4521642 | 0.76 | KIF11 (0.50) | ALDH1A1MEN1KMT2AKIF11CYP2C19 | |
| SCHEMBL5406638 | 0.75 | RGS4 (0.38) | ALDH1A1MEN1KMT2ACYP3A4RGS4 | |
| SCHEMBL4373915 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AKIF11KIF23 | |
| SCHEMBL4516228 | 0.73 | KIF11 (0.55) | ALDH1A1MEN1KMT2AKIF11CYP2C19 | |
| SCHEMBL4524272 | 0.73 | KIF11 (0.55) | ALDH1A1MEN1KMT2AKIF11CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482343-B2 | Compounds, methods and compositions | CYTOKINETICS, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070135432-A1 | Compounds, methods and compositions | CYTOKINETICS, INC. | 2007-06-14 | — | — | US | disclosed |
| US-7166595-B2 | Compounds, methods and compositions | CYTOKINETICS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040077662-A1 | Compounds, methods and compositions | CYTOKINETICS, INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077662-A1 | Compounds, methods and compositions | ALPP, PCNA, MKI67 | ALDH1A1 2640/4885MEN1 1613/4885KMT2A 1902/4885 |
| US-20070135432-A1 | Compounds, methods and compositions | ALPP, PCNA, MKI67 | ALDH1A1 2640/4885MEN1 1613/4885KMT2A 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.