Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251692 | 0.88 | ADAMTS4 (0.47) | LPAR1MMP12MMP2ADAMTS4ADAMTS5 | |
| SCHEMBL2251182 | 0.85 | POLB (0.46) | ADAMTS4ADAMTS5 | |
| SCHEMBL2252342 | 0.85 | HSD17B2 (0.48) | PTGESALOX5HSD17B2ADAMTS4ADAMTS5 | |
| SCHEMBL2247817 | 0.85 | HSD17B2 (0.42) | PTGESALOX5HSD17B2ADAMTS4ADAMTS5 | |
| SCHEMBL2253174 | 0.85 | POLB (0.41) | NPC1ADAMTS4ADAMTS5 | |
| SCHEMBL2249301 | 0.83 | HSD17B2 (0.48) | PTGESALOX5HSD17B2NPC1RAB9A | |
| SCHEMBL5653525 | 0.83 | SRD5A2 (0.44) | PTGESALOX5LPAR1MMP12 | |
| SCHEMBL4369489 | 0.83 | PTGES (0.45) | PTGESALOX5MMP12MMP2RAB9A | |
| SCHEMBL2247300 | 0.83 | HSD17B2 (0.45) | PTGESALOX5HSD17B2LPAR1NPC1 | |
| SCHEMBL2246642 | 0.82 | MMP12 (0.41) | PTGESALOX5MMP12MMP2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | PTGES 1681/4885ALOX5 1774/4885HSD17B2 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.