SCHEMBL4370465

SCHEMBL4370465

Nc1cc2nc[nH]c2cc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 1.00
KDM4E B2RXH2 4/20 1.00
ALDH1A1 P00352 3/20 1.00
TDP1 Q9NUW8 2/20 1.00
APEX1 P27695 1/20 1.00
RECQL P46063 1/20 1.00
BLM P54132 1/20 1.00
PRKCI P41743 1/20 0.57
RAD52 P43351 1/20 0.55
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
MMP12 P39900 1/20 0.42
QPCT Q16769 1/20 0.42
QPCTL Q9NXS2 1/20 0.42
CYP3A4 P08684 1/20 0.41
NAMPT P43490 1/20 0.41
XDH P47989 1/20 0.41
PNP P00491 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5651319 0.98 MAPT (0.95) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL7019075 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL1839055 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL10884699 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL27459919 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL10884689 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL3041015 0.83 MAPT (0.70) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL14511179 0.82 MAPT (0.68) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL12445185 0.79 MAPT (0.65) MAPTKDM4EALDH1A1TDP1APEX1
SCHEMBL31423376 0.78 MAPT (0.63) MAPTKDM4EALDH1A1TDP1APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116333299-B Preparation method of polyol for waterborne polyurethane 上海蓝欧化工科技有限公司 2025-04-08 CN claimed
CN-119060537-A Self-lubricating wear-resistant polyphenylene sulfide-based composite material and preparation method thereof 江西聚真科技发展有限公司 2024-12-03 CN claimed
CN-112426884-A Antibacterial composite reverse osmosis membrane and preparation method thereof 嘉兴市爵拓科技有限公司 2021-03-02 CN claimed
CN-102464676-A Ruthenium (II) polypyridine complex and preparation method and application thereof UNIV TONGJI 2012-05-23 CN claimed
CN-116333299-B Preparation method of polyol for waterborne polyurethane 上海蓝欧化工科技有限公司 2025-04-08 CN disclosed
CN-119060537-A Self-lubricating wear-resistant polyphenylene sulfide-based composite material and preparation method thereof 江西聚真科技发展有限公司 2024-12-03 CN disclosed
US-12018003-B2 Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-06-25 US disclosed
CN-109666160-B Dynamic polymer with hybrid cross-linked network 厦门天策材料科技有限公司 2023-07-14 CN disclosed
CN-116333299-A Preparation method of polyol for waterborne polyurethane 上海蓝欧化工科技有限公司 2023-06-27 CN disclosed
US-20230097164-A1 USE OF MICROBIAL CELL LINES TO MAXIMIZE ORGANIC ACID PRODUCTION S & P INGREDIENT DEVELOPMENT, LLC (US) 2023-03-30 US disclosed
EP-4103688-A1 USE OF MICROBIAL CELL LINES TO MAXIMIZE ORGANIC ACID PRODUCTION S & P Ingredient Development, LLC (US) 2022-12-21 EP disclosed
US-20210309616-A1 SUBSTITUTED QUINAZOLINES AS MATRIX METALLOPROTEINASE-9 HEMOPEXIN DOMAIN INHIBITORS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK 2021-10-07 US disclosed
EP-0150707-B1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MITSUBISHI KASEI CORPORATION (JP) 1988-04-13 EP disclosed
EP-0207483-A2 Benzimidazoles, process for their preparation, medicaments containing them and intermediates Roche Diagnostics GmbH (DE) 1987-01-07 EP disclosed
US-4618555-A PHOTOSENSITIVITY; DURABILITY MITSUBISHI CHEMICAL IND., LTD. (JP) 1986-10-21 US disclosed
EP-0063387-B1 ELECTROPHOTOGRAPHIC PLATE MITSUBISHI KASEI CORPORATION (JP) 1986-07-23 EP disclosed
EP-0150707-A1 Electrophotographic photoreceptor MITSUBISHI KASEI CORPORATION (JP) 1985-08-07 EP disclosed
US-4396696-A Electrophotographic plate having azo compound photosensitive layer MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1983-08-02 US disclosed
EP-0063387-A1 Electrophotographic plate MITSUBISHI KASEI CORPORATION (JP) 1982-10-27 EP disclosed
US-4000135-A IRON TETRAAZANNULENES AS CATALYSTS BASF AKTIENGESELLSCHAFT (DT) 1976-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12018003-B2 Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors MMP9, MMP7, MMP11 MAPT 422/4885KDM4E 1807/4885ALDH1A1 1859/4885
US-20210309616-A1 SUBSTITUTED QUINAZOLINES AS MATRIX METALLOPROTEINASE-9 HEMOPEXIN DOMAIN INHIBITORS MMP2, MMP9, MMP10 MAPT 4268/4885KDM4E 977/4885ALDH1A1 3478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.