Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19202482 | 0.91 | AKR1B1 (0.58) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL8600926 | 0.86 | AKR1B1 (0.60) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL21573719 | 0.85 | NPC1 (0.55) | MAPTLMNAGAATSHRTDP1 | |
| SCHEMBL14299544 | 0.84 | AKR1B1 (0.58) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL9239083 | 0.81 | AKR1B1 (0.53) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL16091077 | 0.81 | AKR1B1 (0.58) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL9509522 | 0.80 | NPC1 (0.66) | MAPTLMNAKDM4EHPGDPOLB | |
| SCHEMBL19202479 | 0.78 | AKR1B1 (0.47) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL3803115 | 0.76 | AKR1B1 (0.58) | AKR1B1MAPTLMNAKDM4EHPGD | |
| SCHEMBL933080 | 0.75 | CA2 (0.62) | AKR1B1MAPTLMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573603-A1 | INHIBITORS OF HUMAN NEUTROPHIL ELASTASE AND HUMAN CATHEPSIN G | Dyax Corp. (US) | 1993-12-15 | — | — | EP | claimed |
| WO-1992015605-A2 | INHIBITORS OF HUMAN NEUTROPHIL ELASTASE AND HUMAN CATHEPSIN G | PROTEIN ENGINEERING CORPORATION (US) | 1992-09-17 | — | — | WO | claimed |
| EP-1325931-B1 | Inhibitors of human neutrophil elastase | DYAX CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20030223977-A1 | Kunitz domain mutants as cathepsin G inhibitors | LEY ARTHUR CHARLES (US) | 2003-12-04 | — | — | US | disclosed |
| EP-1325931-A1 | Inhibitors of human neutrophil elastase | Dyax Corp. (US) | 2003-07-09 | — | — | EP | disclosed |
| EP-0573603-B1 | INHIBITORS OF HUMAN NEUTROPHIL ELASTASE AND HUMAN CATHEPSIN G | DYAX CORP (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0573603-A1 | INHIBITORS OF HUMAN NEUTROPHIL ELASTASE AND HUMAN CATHEPSIN G | Dyax Corp. (US) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015605-A2 | INHIBITORS OF HUMAN NEUTROPHIL ELASTASE AND HUMAN CATHEPSIN G | PROTEIN ENGINEERING CORPORATION (US) | 1992-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030223977-A1 | Kunitz domain mutants as cathepsin G inhibitors | CTSG, SPINT2, CTSZ | AKR1B1 3853/4885MAPT 4272/4885LMNA 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.