SCHEMBL4372185

SCHEMBL4372185

Cc1ccc2c(c1)c1c(n2C)C(N([SiH](C)C)C(C)(C)C)c2ccccc2-1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
MEN1 O00255 1/20 0.33
NR1I2 O75469 1/20 0.33
AHR P35869 1/20 0.33
KMT2A Q03164 1/20 0.33
KDM4E B2RXH2 1/20 0.33
APAF1 O14727 1/20 0.33
MAPT P10636 1/20 0.33
PKM P14618 1/20 0.33
IDO1 P14902 1/20 0.33
MAPK1 P28482 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
MCL1 Q07820 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
USP2 O75604 1/20 0.31
HSD17B10 Q99714 1/20 0.31
NTRK1 P04629 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4373543 0.86 ALDH1A1 (0.44) BCHEACHEMEN1KMT2AKDM4E
SCHEMBL7636376 0.76 MEN1 (0.37) BCHEACHEMEN1NR1I2AHR
Hydrochloric Acid SCHEMBL3923993 0.75 MEN1 (0.36) BCHEACHEMEN1NR1I2AHR
SCHEMBL4375149 0.75 GPR3 (0.36)
SCHEMBL26822553 0.74 MEN1 (0.35) BCHEACHEMEN1NR1I2AHR
SCHEMBL7124338 0.73 MEN1 (0.39) BCHEACHEMEN1NR1I2AHR
SCHEMBL4373398 0.73 ALDH1A1 (0.35) MEN1KMT2AKDM4EMAPTMAPK1
SCHEMBL3221291 0.72 MEN1 (0.31) MEN1NR1I2AHRKMT2A
SCHEMBL4375945 0.71 MEN1 (0.39) BCHEACHEMEN1NR1I2AHR
Hydrochloric Acid SCHEMBL7120127 0.71 MEN1 (0.36) BCHEACHEMEN1NR1I2AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1533324-B1 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method BASELL POLYOLEFINE GMBH (DE) 2009-05-06 EP disclosed
EP-1533324-A2 A ligand for a metallocene catalyst used to prepare propylene based polymers, and its preparation method Basell Polyolefine GmbH (DE) 2005-05-25 EP disclosed
EP-1159310-B1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL POLYOLEFINE GMBH (DE) 2005-03-30 EP disclosed
US-6730754-B2 COORDINATION POLYMERIZATION CATALYST BASELL POLYOLEFINE GMBH (DE) 2004-05-04 US disclosed
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers EQUISTAR CHEMICALS, LP 2002-10-10 US disclosed
EP-1159310-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS Basell Technology Company B.V. (NL) 2001-12-05 EP disclosed
WO-2001053360-A1 PROCESS FOR PRODUCING SUBSTANTIALLY AMORPHOUS PROPYLENE-BASED POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147286-A1 Process for producing substantially amorphous propylene-based polymers GRB7, CHRM1, CPNE4 BCHE 4589/4885ACHE 4057/4885MEN1 2468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.