Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP14 | P50281 | 3/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | EPOR | P19235 | 3/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293042 | 0.92 | LTA4H (0.33) | LTA4HMMP2MMP14MMP9EPOR | |
| SCHEMBL3874559 | 0.89 | NPY4R (0.36) | — | |
| SCHEMBL1799336 | 0.88 | F2 (0.34) | — | |
| SCHEMBL1799060 | 0.87 | SLC9A3 (0.36) | MMP2MMP14ADAM10MMP9ADAM17 | |
| SCHEMBL1800587 | 0.87 | SLC9A3 (0.33) | — | |
| SCHEMBL1800732 | 0.82 | MAP2K1 (0.33) | — | |
| SCHEMBL4371687 | 0.82 | SMN1; SMN2 (0.36) | LTA4HMMP2MMP14MMP9MMP13 | |
| SCHEMBL4375791 | 0.81 | MMP2 (0.42) | LTA4HMMP2MMP14MMP9ADAM17 | |
| SCHEMBL4372331 | 0.79 | ADAM17 (0.58) | MMP2MMP14ADAM10MMP9ADAM17 | |
| SCHEMBL4370906 | 0.78 | SCN9A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |