SCHEMBL4374065

SCHEMBL4374065

FC(F)(F)c1ccc(Oc2ncc(Br)cn2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.47
SLC6A4 P31645 1/20 0.42
FFAR1 O14842 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
MAPT P10636 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LTA4H P09960 1/20 0.39
KCNH2 Q12809 2/20 0.38
SCN9A Q15858 2/20 0.38
SCN5A Q14524 1/20 0.38
LMNA P02545 1/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38
TUBB2A Q13885 1/20 0.38
TUBB8 Q3ZCM7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21801782 0.82 SCN5A (0.40) SLC6A4FFAR1MAPTKCNH2SCN9A
SCHEMBL22405000 0.80 L3MBTL1 (0.50) THRBMAPTNPSR1LTA4HLMNA
SCHEMBL24156362 0.79 MEN1 (0.44) FFAR1MAPTNPSR1LMNATUBB4A
SCHEMBL21330645 0.79 THRB (0.67) THRBMAPTNPSR1LMNAL3MBTL1
SCHEMBL4370646 0.78 KIF11 (0.47) MAPTNPSR1LTA4HKCNH2SCN9A
SCHEMBL4371648 0.78 MAOB (0.54) MAPTLTA4HKCNH2SCN9ASCN5A
SCHEMBL18554989 0.77 FFAR1 (0.40) FFAR1NPSR1LTA4HSCN9ALMNA
SCHEMBL4371434 0.77 SRD5A2 (0.49) MAPTLMNAL3MBTL1RAB9A
SCHEMBL9262733 0.77 SLC6A4 (0.53) THRBSLC6A4TRPV1MAPTLTA4H
SCHEMBL4372801 0.76 GRM4 (0.52) MAPTLMNAMAOBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025262243-A1 THIENO- AND THIAZOLOPYRIMIDINE-2,6-DIONES AND USE THEREOF AS IMMUNOMODULATORS INVIOS GMBH (AT) 2025-12-26 WO disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed