Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458229 | 0.79 | KIF11 (0.68) | KIF11LTA4HCYP3A4CYP3A5CYP19A1 | |
| SCHEMBL4374065 | 0.78 | THRB (0.47) | LTA4HMAOBMAPTNPSR1TTBK1 | |
| SCHEMBL21045811 | 0.75 | DGAT1 (0.44) | KIF11LTA4HCYP19A1MAPTNPSR1 | |
| SCHEMBL6982061 | 0.75 | MAPT (0.57) | KIF11MAPTNPSR1SCN9A | |
| SCHEMBL4371648 | 0.74 | MAOB (0.54) | LTA4HMAOBMAPTKCNH2SCN9A | |
| SCHEMBL4371434 | 0.73 | SRD5A2 (0.49) | MAPTGRM4 | |
| SCHEMBL4371705 | 0.72 | MAOB (0.54) | KIF11MAOBMAPTSCN9AGRM4 | |
| SCHEMBL4372801 | 0.72 | GRM4 (0.52) | MAOBMAPTGRM4 | |
| SCHEMBL8483343 | 0.71 | LTA4H (0.49) | KIF11LTA4HMAOBMAPT | |
| SCHEMBL11097560 | 0.71 | MEN1 (0.45) | KIF11LTA4HMAPTNPSR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |