Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 5/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374524 | 0.83 | ALDH1A1 (0.47) | CCR1HPGDSCTSLLMNANPC1 | |
| SCHEMBL4583485 | 0.83 | ALDH1A1 (0.47) | CCR1HPGDSCTSLLMNANPC1 | |
| SCHEMBL4389462 | 0.83 | HDAC1 (0.45) | LMNAKMT2A | |
| SCHEMBL4581842 | 0.80 | ALDH1A1 (0.40) | CTRB1CCR1CTSLLMNANPC1 | |
| SCHEMBL4375386 | 0.80 | ACKR3 (0.43) | CTSLLMNANPC1RAB9AKMT2A | |
| SCHEMBL4382189 | 0.80 | ACKR3 (0.43) | CTSLLMNANPC1RAB9AKMT2A | |
| SCHEMBL1682690 | 0.80 | GRM5 (0.43) | CCR1KMT2A | |
| SCHEMBL4378512 | 0.78 | AKT1 (0.40) | CCR1LMNAKMT2A | |
| SCHEMBL4377324 | 0.77 | PYGL (0.38) | CTSLNPC1RAB9AKMT2A | |
| SCHEMBL4381061 | 0.77 | RAB9A (0.41) | CCR1CTSLNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |