Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 2/20 | 0.32 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372650 | 0.79 | BMP1 (0.51) | BMP1ADAMTS4MMP1MMP2MMP14 | |
| SCHEMBL4370947 | 0.79 | OPRM1 (0.40) | — | |
| SCHEMBL1799173 | 0.76 | MMP2 (0.41) | HTTBMP1MMP1MMP2MMP13 | |
| SCHEMBL4542075 | 0.75 | HPGDS (0.42) | SCN9A | |
| SCHEMBL4372258 | 0.74 | F2 (0.41) | ALDH1A1BMP1MMP1MMP2MMP13 | |
| SCHEMBL1800832 | 0.73 | F2 (0.37) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL1798846 | 0.71 | DAGLA (0.38) | ALDH1A1MCL1HTTNPSR1LTA4H | |
| SCHEMBL10528975 | 0.66 | SLC6A4 (0.62) | ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL4375791 | 0.65 | MMP2 (0.42) | HTTLTA4HMMP1MMP2MMP13 | |
| SCHEMBL4380644 | 0.64 | MMP2 (0.43) | KMT2AMEN1MMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |