Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.43 |
| ▸ | MMP14 | P50281 | 8/20 | 0.43 |
| ▸ | CA1 | P00915 | 7/20 | 0.43 |
| ▸ | CA2 | P00918 | 7/20 | 0.43 |
| ▸ | CA9 | Q16790 | 7/20 | 0.43 |
| ▸ | MMP8 | P22894 | 6/20 | 0.43 |
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.43 |
| ▸ | MMP16 | P51512 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | EPOR | P19235 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800017 | 0.86 | MMP2 (0.44) | MMP2MMP14MMP8MMP9MMP1 | |
| SCHEMBL1799173 | 0.86 | MMP2 (0.41) | MMP2MMP14CA1CA2CA9 | |
| SCHEMBL4290484 | 0.81 | LMNA (0.38) | MMP2MMP14CA1CA2CA9 | |
| SCHEMBL4372258 | 0.77 | F2 (0.41) | MMP2MMP14MMP9MMP1MMP13 | |
| SCHEMBL4371642 | 0.75 | PTGES (0.48) | MMP2MMP14CA1CA2CA9 | |
| SCHEMBL4371638 | 0.75 | PTGES (0.48) | MMP2MMP14CA1CA2CA9 | |
| SCHEMBL3872450 | 0.74 | MMP13 (0.56) | MMP2MMP14MMP9MMP1MMP13 | |
| SCHEMBL4292057 | 0.73 | TBXA2R (0.38) | MMP2MMP14MMP9MEN1KMT2A | |
| SCHEMBL4382917 | 0.72 | MMP2 (0.40) | MMP2MMP14MMP8MMP9MMP1 | |
| SCHEMBL6757287 | 0.72 | MMP1 (0.46) | MMP2MMP14MMP8MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |