Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384037 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL5403784 | 0.83 | L3MBTL1 (0.41) | CTSSATMKMT2AL3MBTL1MEN1 | |
| SCHEMBL31153865 | 0.77 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL1274248 | 0.75 | KDM4E (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL4352633 | 0.75 | KDM4E (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL29193580 | 0.75 | CYP2C19 (0.42) | MAPTCTSSCTSKATMKMT2A | |
| SCHEMBL17780016 | 0.74 | CHRNB2 (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4CTSS | |
| SCHEMBL8001138 | 0.74 | MAPT (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL4795572 | 0.74 | CTSK (0.36) | MAPTCTSSCTSKATMKMT2A | |
| SCHEMBL17776389 | 0.74 | CHRNB2 (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121676-A1 | PREPERATION AND UTILITY OF CCR5 INHIBITORS | Auspex Pharmaceuticals, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077103-A1 | PREPERATION AND UTILITY OF CCR5 INHIBITORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| US-20080146605-A1 | PREPARATION AND UTILITY OF CCR5 INHIBITORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146605-A1 | PREPARATION AND UTILITY OF CCR5 INHIBITORS | CCR5, CCR8, CCL5 | CHRNB2 886/4885CHRNB4 1538/4885CHRNA3 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.