Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.64 |
| ▸ | NCF1 | P14598 | 1/20 | 0.64 |
| ▸ | METAP2 | P50579 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | COMT | P21964 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31424217 | 1.00 | PLAU (0.64) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1946689 | 0.98 | PLAU (0.62) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| Sulfuric Acid SCHEMBL7561856 | 0.91 | KDM4E (0.59) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| SCHEMBL14337175 | 0.86 | PLAU (0.48) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| SCHEMBL361523 | 0.78 | NCF1 (1.00) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| SCHEMBL29683992 | 0.77 | SLC40A1 (0.45) | PLAUNCF1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL21767732 | 0.77 | METAP2 (0.63) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| SCHEMBL30082244 | 0.77 | METAP2 (0.63) | PLAUNCF1METAP2ALOX12ALDH1A1 | |
| SCHEMBL845037 | 0.77 | SLC40A1 (0.45) | PLAUNCF1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL672744 | 0.77 | METAP2 (0.63) | PLAUNCF1METAP2ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 838 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-220702584-U | Vacuum material absorbing structure and 5-chloro-8-hydroxyquinoline purifying device | 沁阳泓盛精细化工有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-116769157-A | Poly alpha-oximido amide compound and preparation method and application thereof | 华南理工大学 | 2023-09-19 | — | — | CN | claimed |
| CN-115417892-A | Isoxazole substituted boron-nitrogen heterocyclic compound and synthetic method thereof | 福州大学 | 2022-12-02 | — | — | CN | claimed |
| CN-115073442-A | Disulfide bond-containing compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-09-20 | — | — | CN | claimed |
| EP-3878851-A1 | PROCESS FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2021-09-15 | — | — | EP | claimed |
| CN-107406394-B | Process for the preparation of substituted phenylisoxazoline derivatives | 拜耳作物科学股份公司 | 2021-09-03 | — | — | CN | claimed |
| CN-112521402-A | 1,2, 4-oxadiazole [5,5] bicyclic fused ring compound and preparation method thereof | 北京理工大学 | 2021-03-19 | — | — | CN | claimed |
| CN-108997171-B | Synthetic method of 3+2 closed ring | 苏州正济医药研究有限公司 | 2020-11-27 | — | — | CN | claimed |
| US-10822331-B2 | Processes for preparing ATR inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-11-03 | — | — | US | claimed |
| CN-107629020-B | 4H-1,2, 4-oxadiazine-5 (6H) -ketone compound and synthetic method thereof | 湖北科技学院 | 2020-09-04 | — | — | CN | claimed |
| EP-2751097-A2 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2014-07-09 | — | — | EP | claimed |
| CN-103638030-A | Application of nitrosylruthenium complexes taking 2-chloro-8-hydroxyquinoline as ligand | UNIV SHANXI | 2014-03-19 | — | — | CN | claimed |
| US-20130184292-A1 | Processes for Making Compounds Useful as Inhibitors of ATR Kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | claimed |
| WO-2013049726-A2 | PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-04 | — | — | WO | claimed |
| EP-0726268-B1 | Substituted benzisoxazole and benzisothiazole herbicidal agents | AMERICAN CYANAMID CO (US) | 2000-11-02 | — | — | EP | claimed |
| CN-1135420-A | Anti-counterfeiting fluorescent pressure-sensitive carbon paper and manufacturing method thereof | GEDE ANTIFAKE TECH CO NANKAI U (CN) | 1996-11-13 | — | — | CN | claimed |
| EP-0096457-B1 | INDIUM COMPLEXES OF SUBSTITUTED 8-HYDROXY-QUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIBACTERIAL AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1987-03-11 | — | — | EP | claimed |
| EP-0013111-B1 | 3'-(SUBSTITUTED PHENYL)-SPIRO(ISOBENZOFURAN-1(3H),5'(4'H)-ISOXAZOL)-3-ONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS HERBICIDES AND PLANT GROWTH REGULANTS AND THEIR APPLICATION TO THE PREPARATION OF ISOXAZOLE DERIVATIVES | MONSANTO COMPANY (US) | 1984-02-22 | — | — | EP | claimed |
| EP-0013111-A2 | 3'-(substituted phenyl)-spiro(isobenzofuran-1(3H),5'(4'H)-isoxazol)-3-ones, process for their preparation, their use as herbicides and plant growth regulants and their application to the preparation of isoxazole derivatives | MONSANTO COMPANY (US) | 1980-07-09 | — | — | EP | claimed |
| US-4209629-A | HERBICIDES, PLANT GROWTH REGULATORS | MONSANTO COMPANY (US) | 1980-06-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822331-B2 | Processes for preparing ATR inhibitors | ATR, ATRIP, CHEK1 | PLAU 4279/4885NCF1 2340/4885METAP2 3476/4885 |
| US-20130184292-A1 | Processes for Making Compounds Useful as Inhibitors of ATR Kinase | ATR, ATRIP, CHEK1 | PLAU 4207/4885NCF1 2045/4885METAP2 3273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.