Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28918253 | 0.81 | HTR1D (0.42) | MTNR1AMTNR1BALDH1A1NPSR1KDM4E | |
| SCHEMBL27099115 | 0.76 | ALDH1A1 (0.68) | HPGDCYP2C19ALDH1A1NPSR1KDM4E | |
| SCHEMBL10550018 | 0.75 | LTA4H (0.60) | MTNR1AMTNR1BHPGDALDH1A1NPSR1 | |
| SCHEMBL28665575 | 0.75 | CYP4F2 (0.42) | HPGDCYP2C19ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL4500910 | 0.73 | MTNR1A (0.62) | MTNR1AMTNR1BCYP2C19TSHRMAPT | |
| SCHEMBL29190392 | 0.73 | PTGS2 (0.38) | HTR1AHTR1DHTR1BKMT2AICMT | |
| SCHEMBL16791392 | 0.73 | HPGD (0.68) | HPGDCYP2C19ALDH1A1NPSR1KDM4E | |
| SCHEMBL29026421 | 0.72 | GSK3B (0.42) | ICMT | |
| SCHEMBL14493805 | 0.72 | MTNR1A (0.72) | MTNR1AMTNR1BHPGDCYP2C19ALDH1A1 | |
| SCHEMBL31543734 | 0.72 | MTNR1A (0.72) | MTNR1AMTNR1BHPGDCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |