Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001227 | 0.97 | THRB (0.47) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL3006717 | 0.96 | THRB (0.42) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL3002042 | 0.92 | PLA2G4A (0.43) | MAPTLMNAALDH1A1ALOX12NPSR1 | |
| SCHEMBL4093752 | 0.92 | LMNA (0.46) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL4098737 | 0.91 | L3MBTL1 (0.41) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL4096099 | 0.90 | FAAH (0.46) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL3001761 | 0.90 | LMNA (0.46) | THRBMAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL4088421 | 0.88 | PLA2G2A (0.43) | THRBMAPTLMNATP53MEN1 | |
| SCHEMBL4090425 | 0.88 | CNR1 (0.42) | MAPTLMNAALDH1A1ALOX12EPHX2 | |
| SCHEMBL3000373 | 0.87 | MAPT (0.43) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |