Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473794 | 0.83 | SIRT2 (0.40) | DPYDPOLBPNPLTA4HPLA2G2A | |
| SCHEMBL6472862 | 0.82 | IMPDH2 (0.40) | DPYDPOLBPNPMAPTKDM4E | |
| SCHEMBL6472151 | 0.80 | PARP10 (0.49) | DPYDPNPPLA2G2AKDM4EMAOB | |
| SCHEMBL6652475 | 0.80 | DPYD (0.41) | DPYDPOLBPNPPPARGTHRA | |
| SCHEMBL6472836 | 0.80 | NR4A1 (0.47) | DPYDPNPKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL6471088 | 0.80 | THRA (0.45) | DPYDPOLBNSD2ABL1PPARG | |
| SCHEMBL4379215 | 0.79 | MAPT (0.41) | DPYDMAPTMAOBL3MBTL1LMNA | |
| SCHEMBL6472152 | 0.79 | MAOB (0.47) | DPYDPOLBPNPMAOBGAA | |
| SCHEMBL6471484 | 0.78 | DPYD (0.46) | DPYDMAPTKDM4ETHRATHRB | |
| SCHEMBL6647198 | 0.78 | PNP (0.40) | DPYDPOLBPNPPLA2G2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |