Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 5/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372598 | 0.89 | NR3C1 (0.48) | NR3C1PGRPTGESDAGLAALOX5 | |
| SCHEMBL4382976 | 0.81 | NR3C1 (0.56) | NR3C1PGRTAS2R14PTGESACACB | |
| SCHEMBL4562616 | 0.74 | LMNA (0.39) | NR3C1PTGESDAGLAMMP8MMP3 | |
| SCHEMBL4377727 | 0.73 | MMP2 (0.59) | KEAP1LMNATSHRMMP2MMP9 | |
| SCHEMBL6757292 | 0.73 | PTGES (0.42) | NR3C1PTGESDAGLAMMP8MMP3 | |
| SCHEMBL4374490 | 0.73 | DPP4 (0.39) | ALOX5MMP13 | |
| SCHEMBL3870207 | 0.71 | MMP2 (0.61) | MMP3MMP1MMP2MMP9MMP13 | |
| SCHEMBL6724678 | 0.71 | MMP2 (0.52) | MMP3LMNAHTTMMP1MMP2 | |
| SCHEMBL4375791 | 0.70 | MMP2 (0.42) | PTGESMMP8MMP3LMNAHTT | |
| SCHEMBL515521 | 0.70 | SLC7A5 (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |